Instructions for use of Viferon 3000000 IU suppositories

Introduction

Currently, there is a wide variety of drugs with immunomodulatory activity on the pharmacological market.

One of these drugs are Viferon suppositories 3,000,000 IU. It is a broad-spectrum drug prescribed for many viral and bacterial infections.

Purpose of the suppository

These candles have the following pharmacological effects:

• immunomodulation;
• antiviral action;
• antiproliferative effect.

Medication Descriptions

A yellow or white-yellow candle has the shape of a bullet. The suppository diameter is less than 1 cm.

For ease of insertion into the rectum, there is a recess at the blunt end of the suppository.

Release form

Rectal suppositories Viferon 3000000 IU are available in a cardboard box of 5 or 10 pieces. Candles are in a PVC package divided into 5 or 10 cells. Each candle is in a separate cell for easy extraction.

Composition and main active ingredient

The main active substance of the drug is interferon alpha-2b human recombinant . Each suppository contains 3,000,000 IU of the active ingredient.

In addition to it, the composition contains additional components:

• ascorbic acid;
• alpha-tocopherol;
• polysorbate;
• sodium ascorbate;
• cocoa butter substitute.

ATX code

The ATC code for this drug is L03AB05 (interferon alfa-2b).

Pharmacokinetics

Candles Viferon 3000000 IU are applied topically. With this method of administration, the absorption of interferon is extremely small, which does not allow tracking the metabolism of a substance in the body.

Pharmacodynamics

Human recombinant interferon alfa-2b has antiviral, immunomodulatory and antiproliferative qualities.

The main active ingredient of the drug causes suppression of the formation of viral RNA and DNA, due to which the drug has an antiviral effect.

Together with alpha-tocopherol and ascorbic acid, interferon alpha-2b increases the activity of phagocytes and leukocytes against bacterial and viral agents, against the background of the use of Viferon, the level of secretory immunoglobulin A increases, which provides the immunomodulatory activity of the drug.

Instructions for use for adults

Viferon has multiple antiviral and antibacterial activity. The mode of taking the drug depends on the nature of the disease.

Indications for use

Candles Viferon 3000000 have a wide range of indications for admission:

• in combination with other medicines in the treatment of acute respiratory viral infections, including those complicated by bacterial pneumonia;
• in combination with other medicines in the treatment of chronic viral hepatitis B, C, D, including those complicated by cirrhosis of the liver;
• complex treatment of infectious diseases of the genital tract (chlamydia, mycoplasma, trichomonas, papillomavirus and cytomegalovirus infections, ureaplasmosis, bacterial vaginosis, human papillomavirus infection, relapses of vaginal candidiasis;
• herpetic infection of the skin and mucous membranes of any localization (primary and recurrent).

Receive mode

Candles Viferon are used rectally. The suppository must be applied immediately after being removed from the package in order to avoid its melting.

The suppository must be inserted deep into the rectum, put it behind the external anal sphincter. After the introduction of the suppository, it is recommended to be in a horizontal position for some time in order to avoid the suppository falling out of the rectum. The dosage of the drug depends on the reason for the use.

For the combined treatment of acute respiratory viral infections, including those complicated by bacterial pneumonia, suppositories are used at a daily dose of 1,000,000 ( 500,000 IU  2 times a day) for 5 days (longer if necessary).

In the complex therapy of chronic viral hepatitis B, C, D, including those complicated by liver cirrhosis, the recommended dose of Viferon 3000000 is 1 suppository 2 times a day with an interval of 12 hours for 10 days, then continue the administration of suppositories 3 times a week for 6–12 months.

The duration of treatment for viral hepatitis is determined by a specialist after assessing the patient’s condition and laboratory data.

In the treatment of genital infections, together with other drugs, Viferon suppositories are prescribed at a dose of 50,000 IU, one suppository 2 times a day for 5–10 days. If it is necessary to increase the duration of treatment, you should consult with a specialist.

In the treatment of primary or recurrent infection caused by the herpes simplex virus, suppositories are prescribed at a dose of 1,000,000 IU, one suppository 2 times a day for 10 days.

Treatment should begin at the first signs of exacerbation (redness, itching). Treatment started when the first symptoms appear is the most effective. If necessary, the course of therapy should be continued after consulting a doctor.

However, the doctor may prescribe suppositories in this dosage for severe acute respiratory viral infections, influenza, herpes or genital infections, as well as for patients with a large excess weight, since the effectiveness of the drug at a low dose in overweight people may be insufficient.

In this case, the calculation of the recommended dose is made according to special nomograms. Exceptions are pregnant women. They appoint Viferon strictly in accordance with the instructions.

Nuances of use during pregnancy and during breastfeeding

Candles Viferon are contraindicated for use in the first trimester of pregnancy. The drug is allowed from 14 weeks of gestation. Minimum effective dosages are prescribed.

Side effect

In persons with hypersensitivity to the drug, allergic manifestations (usually local) to any component of the drug may occur. Possible manifestations of allergies:

• itching;
• skin redness;
• swelling in the injection area;
• rash like urticaria.

In what cases is the medication contraindicated?

The use of suppositories is contraindicated in case of individual hypersensitivity to the active substance or any additional component of the drug, which is manifested by various allergic reactions.

special instructions

Due to the low systemic absorption, there is no effect on driving.

Interaction with other pharmaceutical drugs

Due to the low concentration in the blood, it is impossible to assess the interaction with other drugs, however, clinical practice shows good compatibility of Viferon 3000000 suppositories with antibacterial agents, glucocorticosteroids and chemotherapy drugs.

The immunomodulatory effect of interferon in some cases makes it possible to reduce the dose of antibacterial drugs and glucocorticosteroids, which reduces the risk of side effects when they are taken.

Is it possible to combine with alcoholic beverages

The components of the suppository due to the low concentration in the blood do not interact with ethyl alcohol.

The order of issue and the cost of packaging

Candles are dispensed freely, no prescription is required.

The cost of packing suppositories in the amount of 10 pieces ranges from 850–950 rubles, depending on the region and the individual pricing policy of pharmacy chains.

Storage conditions and shelf life

Candles must be stored in the refrigerator at a temperature of 2-8 ° C, out of the reach of children.

The shelf life of the drug, subject to temperature conditions, is 2 years. Do not use suppositories after the expiration date or in violation of storage conditions.

Analogues of rectal suppositories

On the pharmaceutical market, there are other preparations in the form of suppositories with immunomodulatory activity based on human interferons.

The most popular analogues include the following drugs:

• Kipferon.
• Genferon.
• Giaferon.
• Interal, etc.

Feedback from patients and doctors

Reviews of doctors and patients about this drug are somewhat contradictory.

• In my opinion, Viferon is an excellent drug. We have been using it for over 4 years now. For colds and flu, this is our first remedy. And charging the immune system at any time is not too late, especially in case of illness, he needs help.
• I am usually treated with viferon suppositories, they help me very well from the flu. With them, the general condition improves, I put it on and every day it gets easier, and all the symptoms disappear.
• Very often I prescribe this drug in gynecology . I note high efficiency in the complex treatment of diseases of the female genital area.
• It can also be prescribed to pregnant women and children, which is also extremely positive. Convenient to use when administered to children. Good for boosting the immune system.
• The drug without a clear evidence base, this limits its use in clinical practice. Sexually transmitted infections go away without it with the right antimicrobial therapy.

Conclusion

Suppositories Viferon 3000000 IU are an effective tool that increases the body’s own resistance to various infections. To prescribe the correct regimen for taking the drug, you must consult a doctor.