This article will help you better understand a drug such as Interferon alpha-2b.
Here will be given the properties of the drug, indications, methods of application. Analogues of this tool. Also the results of research and testing, the use of the drug for HPV.
Содержание:
What is the description of the active ingredient?
This substance serves as the basis for the creation of many drugs in the fight against various diseases. And later in the article, you will learn more about this substance, what properties it has and in what cases it is used.
What is this drug?
This drug is an antiviral agent, used to treat viral diseases, also in some types of cancer.
Like all other drugs related to interferons, it has pyrogenic properties. Included in the group of drugs-immunomodulators and immunostimulants used in the treatment of diseases.
Production takes place, under a plurality of different trade names, is part of a number of combined medicines.
Pharmacological properties
Pharmacological properties – immunomodulatory, antitumor, antibacterial, anti-inflammatory, antiviral.
This drug is a collection of different subtypes of natural alpha-interferon, which is found in human blood leukocytes.
Due to interaction with receptors on the cell surface, it initiates a complex chain of changes inside cells. There are suggestions that these processes are associated with stopping the replication of viruses in the cell, immunomodulating action and preventing cell proliferation.
It has the effect of phagocytic activity of macrophages, cytotoxic activity of T-cells and “natural killers”. These properties and due to the therapeutic effect of this drug.
It is used as an injection in the treatment of hepatitis C. It is also used in chronic forms of hepatitis B, chronic myeloid leukemia, multiple myeloma, follicular lymphoma, carcinoid tumors and malignant melanoma.
It also takes place with herpes, chlamydia, papillomatosis, melanoma, Kaposi’s sarcoma, cancer of the kidneys, bladder, ovaries, leukemia. Also suitable for various disorders, diseases of the nervous system and multiple sclerosis.
Instructions for use in the treatment of papillomavirus
Indications for prescribing treatment, by a doctor, using this drug, may be as follows: numerous papillomas and warts on the skin of the face, neck, palms, and abdomen.
In fact, they can be anywhere on the skin of your body. These symptoms serve as direct indications for the appointment as a treatment, this drug.
All of the above neoplasms are visually unaesthetic growths that may not cause physical pain to their wearer, but may indicate serious problems, including HPV.
Trade names
As previously mentioned in the article, this drug has a large number of trade names. The following is a list of them:
- Lifeferon.
- Interferon alpha-2b human recombinant.
- Realdiron.
- Interferal.
- Interferon alpha-2 human recombinant.
- Interferon alpha-2b human recombinant (rhIFN-a2b).
- Interferon alpha-2 human recombinant (IFN alpha-2 chr).
- Interferon alpha-2b human recombinant methionine-free.
- Alfaron.
- Altevir .
- Intron A.
Accordingly, given that all these drugs are based on the same drug, interferon alfa-2b, there is no significant difference between them, if only in price.
Forms of drug release
The release of this drug takes place in the form of a lyophilized powder intended for the manufacture of an injection solution. It is produced in the following dosages: 100 thousand, 1, 3, 5, 6, 9 and 18 million IU.
Recommended ways of application and dosage
This drug is used as an intramuscular, subcutaneous and intravenous injection as an injection (you need to dissolve it in saline).
Also, the use occurs intranasally or rectally. In general, the method of application depends on the diagnosis, the form of the course of the disease, the results of laboratory tests and is prescribed only by your doctor.
Adult dosages are recommended, ranging from 1-18 million IU (medical units), the method of administration of which depends on the choice of your doctor.
The number of applications varies from twice a day to once a week. Both dosage and frequency of use of the drug may vary, according to your doctor’s prescription. It depends on the specific diagnosis, on the degree of improvement, or deterioration in health.
The duration of the course can last as a few days, and up to a year. In the latter case, the drug is used as an immunostimulant, consumed in minimal dosages.
Means analogues
There are many analogues of interferon alpha-2b. Following is a list of them:
- Reaferon.
- Okoferon.
- Alfarekin.
- Pegasys.
- Vitaferon.
- Alfaron.
In general, the original and its analogues do not have any significant differences, they can be seen in price fluctuations. Accordingly, it is more likely that the analogue will cost less. But in any case, it is important to understand which drug you should take, only the attending physician can decide.
Has the effectiveness of drug therapy for HPV been proven?
This is a fairly common remedy and is often used in the treatment of various diseases. Accordingly, various clinical studies have been carried out on this remedy.
Including the impact of therapy for HPV, where there were noticeable improvements in the progress of the fight against this diagnosis. Further, these cases will be described in the article.
Clinical Trials
The trials involved sixty women diagnosed with high-risk HPV. Qualitative and quantitative determination of HPV-VR (16, 18, 31 , 33, 35 , 39 , 45, 51, 52 , 56 , 58 , 59 ) in samples was carried out using real-time PCR.
Two groups were created: the participants in group number one used the interferon alfa therapeutic agent in the form of rectal suppositories, while group number two did not receive this agent. One month later, the final examination was carried out.
The average age in the group under the first number was 31.7 with a difference of one and a half years, either more or less, in the group under the second number, the average age was 35 years, again with a difference of about one and a half years (plus, minus).
In the first group, monoinfection occurred in 72.4% of cases, combined infection in 27.6% of cases, in the second group – in 64.3% and 35.7% of cases, respectively.
The average viral load in group number one showed the following results – 3.5 ± 0.2 Lg (HPV/105 cells), group number two showed 3.4 ± 0.3 Lg (p = 0.473).
Clinically significant viral load had to be more in the first group and gave results in the form of -41.4%, insignificant viral load – in the second group there were indicators – 42.9%.
The average viral load in the last study in the first group was 1.9 ± 0.3 Lg (HPV/105 cells), and in the second it was 2.8 ± 0.4 Lg (p = 0.04).
The difference in viral load during the first survey period and one month later was statistically significant in both groups (p < 0.05).
In group number one, HPV elimination occurred in 34.5% of cases, group number two – in 28.6%. Viral load in the group where participants were given the drug (group number one) decreased by 45.5%, in the group where people did not receive it (group number two) – the decrease was only 18.3% (p = 0, 01).
Research results
According to the results of the above studies, the positive effect of this drug in the fight against HPV has been proven. This is seen in the reduction in viral load in women diagnosed with HPV. who are in their reproductive years.
This article will be especially relevant for people without any medical education, and in principle not interested in medicine.
To improve understanding of how interferon alfa-2b works in therapy if you have a prescription for it. Also, general information regarding this remedy will be very useful. Refer to this article, if you have any questions about this drug, also do not forget to consult with doctors.
