Instructions for use of Rufron suppositories

Introduction

One of the best medicines are those whose main active ingredient is close in composition to the body’s natural enzymes.

These include Ruferon. The drug contains interferon, a substance secreted by the body to fight inflammation.

Characteristics of the drug

Ruferon is a rounded cylindrical candle (suppository) of light yellow color. The coloring is quite uniform, it may contain small defects in the form of light marbling. The shape of the candle may not be ideal – it may contain recesses or internal voids.

Dosage form

Standard release form: cardboard box containing two blister packs, five candles each. Each package also contains instructions for use.

Composition and main active ingredient

The composition of the portion of the drug includes: ascorbic acid, polysorbate, fatty base, as well as human recombinant interferon.

Depending on the form of release, the concentration and degree of activity of interferon, the main active substance, differ.

Pharmacological properties

Ruferon has an antiviral effect based on the suppression of the replication of DNA and RNA viruses. Also, the active substance mobilizes the body’s immune system. This happens due to an increase in the activity of blood phagocytes and an increase in their interaction with target cells.

Ascorbic acid acts as a catalyst, enhancing the properties of interferon. However, it also acts on its own, showing the properties of an antioxidant, and also activates the processes of tissue regeneration.

After the use of the drug, the production of immunoglobulins is enhanced, as well as the secretion of its own interferon. Ascorbic acid, in turn, restores the membranes of cells damaged by viruses.

The principle of action of the drug on HPV

HPV (human papillomavirus) occurs when a specific strain of the virus enters the mucous membranes of the body. Further, warts, papillomas or condylomas form on the infected surface. At the same time, the mucous membrane itself becomes inflamed.

If symptoms of HPV are detected, a specialist consultation is required, since some strains of the virus exhibit oncogenic activity. However, in most cases, patients are prescribed antiviral drugs , which include Ruferon.

Inflammation of the mucosa is a factor that prevents the direct local effect of many antiviral drugs, since they will not penetrate deep into the tissue, where the main focus of infection is located.

When using rectal suppositories, antibodies penetrate directly into the blood. This allows you to influence the body as a whole and fight the virus from the inside. The use of Ruferon, among other things, also has an immunostimulating effect that prevents the development and spread of HPV.

Dosages

The number of candles in the package does not differ (10 in each box). However, there is a gradation of the drug depending on the dosage of interferon. There are four types of Ruferon: 150, 250, 500 or 1000 thousand IU of the active substance (“international units” or “action units”).

However, for a weakened organism (during pregnancy or early age), small concentrations of interferon are preferable.

Ruferon-Rn 150000 IU and 250 tons IU suppositories instructions for use

For suppositories with a dosage of 150 thousand IU,  it is recommended to use 2 times a day for 5 days. The drug is especially effective for infants.

For children from one to seven years of age, a higher dosage of 250 thousand IU is required. The drug is also used twice a day for five days.

The course (if necessary or to consolidate the result) can be repeated, but not earlier than after 5 days.

Nuances of application in pediatrics and gynecology, is it possible for children?

In pediatrics, only varieties of Ruferon with a weak dosage (up to 250 thousand IU) are used. The drug has an antibacterial and anti-inflammatory effect even with complications and intrauterine infection.

However, it is worth remembering that Ruferon has contraindications, such as: malformations, some types of bronchitis, or the course of diseases associated with a violation of the body’s immunity (thyroid disease or HIV).

In some sources, there is little study of the drug with regards to the treatment of children under 6 months. During this period, it is recommended to refrain from self-treatment with Ruferon and consult a pediatrician on this matter.

In gynecology, the method of application is exactly the same. Suppositories are administered rectally, and the active substances enter the bloodstream. The concentration of interferon in gynecological diseases is much higher (from 500 to 1000 thousand IU).

Apply Ruferon for a longer period (up to ten days). For mild female diseases, the concentration used is 500 tons IU. For chronic – 1000 tons IU. In this case, treatment  should be carried out by both partners, in order to avoid cross-infection and the risk of complications.

For the best effect, before using Ruferon, it is recommended to cleanse the intestines, and also take the drug at the same time in order to maintain a constant concentration of interferon in the blood.

Side effects

The only recorded side effect is an allergy with individual intolerance to the components of the drug. An allergic reaction is characterized by itching and redness. However, after stopping Ruferon, these symptoms disappear within two to three days.

What to do in case of overdose

When using Ruferon, there were no cases of overdose. However, if after using the drug, in the doses indicated by the instructions, there is a deterioration in well-being, it is recommended to immediately stop taking it and consult a specialist.

Some consumers attribute a sudden rise in temperature to the effect of an overdose. However, this is a normal effect of exposure to immunostimulating drugs.

special instructions

As noted earlier, Ruferon should be associated with preliminary bowel cleansing (in a natural way, with little exposure to laxatives or enemas).

In case of damage to intimate tissues, the course of treatment is carried out together with a partner. Use the drug should only be prescribed by a doctor and in accordance with the instructions.

drug interaction

Ruferon goes well with many drugs. This allows for complex treatment of viral diseases without harm to the body.

Moreover, interferon can enhance the effects of certain drugs, allowing them to be reduced in dosage. These drugs include substances that have neurotoxic, myelotoxic or cardiotoxic effects on the body.

A noticeable negative effect of Ruferon was found only on drugs that have a narcotic or oxidative nature. In this case, you should take them under the supervision of your doctor and monitor the concentration of both drugs using a blood serum test.

Alcohol compatibility

The interaction of the drug with alcohol is poorly understood. However, many experts note that such joint use can lead to unpredictable consequences. Therefore, it is better to refuse the use of alcohol during the period of application of Ruferon (as well as most antibiotics).

Use during pregnancy and lactation

Pregnant and lactating mothers are not recommended to use the drug. However, in some cases, the drug may be prescribed by a doctor.

Self-medication during this period is prohibited. Despite the small amount of data on the effect of Ruferon on lactation and fetal development, you should not take it thoughtlessly.

Main contraindications

Ruferon has a detrimental effect if the patient has a violation of the functions of the blood or kidneys. It should not be taken during exacerbation of allergic autoimmune reactions. It is also contraindicated in bronchitis, if the course of treatment includes the use of glucocorticosteroids.

Ruferon is practically useless if the patient’s immune system is impaired: there are diseases such as HIV or thyroid damage.

Reviews and prices

For a short history of use, the drug managed to acquire mixed consumer reviews.

Mostly those who did not self-medicate and used Ruferon only as directed by a doctor, in strictly indicated doses, speak positively about him. In these cases, people noted a significant improvement in well-being.

Warmly speak about the drug and the fair sex. He alone helped to cope with many gynecological diseases, including chronic thrush.

Others note the extreme effectiveness of the drug in the treatment of viral diseases in children. The latter is due to the fact that rectal suppositories do not harm the child’s intestinal tract and do not affect his digestion in any way.

Negative reviews are associated with a deterioration in the well-being of some patients after taking the drug. Some of them quickly and quite sharply increased the temperature.

Doctors on this account answer rather succinctly. This reaction is associated with the body’s natural response to viruses. The immune system, activated by interferon, raises body temperature to weaken pathogens. However, this reaction of the body is quite unpleasant for many consumers.

There is also a myth that Ruferon is addictive very quickly. Allegedly, prolonged exposure to the drug weakens its own immune system and the body, after a while, becomes unable to cope with diseases on its own. However, when using the drug as prescribed by the doctor and in accordance with the instructions, this effect was not observed.

It should be noted that Ruferon refers to fairly expensive drugs. On average, for packaging, you will have to pay more than 500 rubles. There are also many negative reviews associated with this.

Analogues

Interferon is a popular active substance in the field of drug treatment. In other words, Ruferon has quite a few analogues. Many of them are tailored for specific needs and local applications (eye drops, nasal spray). The most famous is Vitheon, very similar in composition and release form.

If you search for the main active ingredient – interferon, then the pharmacy can offer you: Bioferon, Alfarekin, Grippferon and many others.

Conclusion

Ruferon is an extremely effective, albeit expensive drug. The release form allows it to be used without harm to the digestive tract, and also used to treat children.

It is recommended to store the drug in the refrigerator, at a temperature not exceeding 10 degrees. Before using the drug, the approval of the attending physician should be obtained, even though Ruferon is available without a prescription.