Composition, instructions for use of Polioxidonium for injections, analogues of the drug

Polyoxidonium is an immunomodulatory drug with a wide spectrum of action.

The drug is actively used to prevent infectious and non-infectious diseases associated with a decrease in the protective functions of the body, and is also used as part of complex therapy for children and adults.

Release form and composition of injections

The drug Polyoxidonium  is produced in the form of a lyophilisate for the preparation of a medicinal solution intended for local therapy and intramuscular injections. The product is sold in hermetically sealed dark glass bottles packed in cardboard boxes.

The main active ingredient of the drug is azoximer bromide, which has the ability to activate the factors of early defense of the body against various infections.

In addition to the main component, the composition contains auxiliary ingredients, including mannitol and povidone. Substances of plant origin and potentially dangerous antigens are not included.

Pharmacological characteristics, is the drug suitable for increasing immunity?

The use of the drug Polyoxidonium allows you to normalize the immune status, increase the body’s resistance to infectious diseases and reduce the duration of treatment in the presence of various pathologies.

Polyoxidonium effectively restores immunity in secondary immunodeficiency states caused by autoimmune diseases, infections, complications after surgical interventions, malignant neoplasms and the use of chemotherapeutic agents.

In addition, the drug reduces the toxicity of other drugs, increasing the resistance of cell membranes to their damaging effects.

Why is the drug prescribed

Polyoxidonium lyophilisate is prescribed after diagnosing such diseases and pathological processes as:

• benign neoplasms of viral etiology (warts, papillomas);
• allergic dermatitis;
• chronic infectious and inflammatory diseases;
• rheumatoid arthritis;
• intestinal dysbacteriosis;
• bronchial asthma;
• oncology;
• tuberculosis;
• radiation dermatitis;
• fractures, ulcers, or burns.

Efficacy in HPV

In case of papillomavirus, Polyoxidonium  is prescribed as an immunomodulating agent, which provides an increase in the protective functions of the body and helps to eliminate both the virus itself and its symptomatic manifestations, which proves the high effectiveness of the drug.

Instructions for the use of injections, how to dilute the solution, how to inject intramuscularly?

It is necessary to use the drug strictly according to the instructions, where the exact dosages for adults and young patients are indicated.

For adults (ampoules, 6 mg)

For intramuscular administration, the lyophilizate (6 mg) is dissolved in 2 ml of 0.9% sodium chloride solution or distilled water, after which the mixture is left for 2-3 minutes and mixed with rotational movements. It is not necessary to shake the solution.

For children

To prepare a treatment solution, dissolve 3 mg of powder in 1 ml of distilled water or sodium chloride. Leave the mixture for a few minutes and mix thoroughly.

During pregnancy and lactation

No teratogenic or embryotoxic effect of the drug was detected during the experiments, however, the instructions indicate that it is undesirable to use the drug for pregnant and lactating women.

For impaired renal function

In chronic renal failure, injections are carried out no more than twice a week. In acute renal failure, the drug in the form of a lyophilisate is not used.

For impaired liver function

For patients with impaired liver function, the drug is prescribed only in case of urgent need.

Consequences of an overdose

Cases of overdose when using the drug Polyoxidonium in prescribed doses have not been recorded. However, the manufacturer does not exclude the possibility of increasing the manifestations of adverse reactions with an independent increase in the therapeutic dose of the solution for subcutaneous injections.

Contraindications for use

The list of contraindications to the use of the drug includes several items:

• individual intolerance to the components that make up the drug;
• acute renal failure;
• pregnancy and lactation;
• age less than 6 months.

Side effects

Polyoxidonium is easily tolerated by the body without causing serious complications, however, if the instructions for use of the drug are not followed, the use of a pharmacological agent can lead to the following symptoms:

• peeling of the skin;
• rashes in the form of small bubbles;
• red spots on the skin;
• swelling of the mucous membranes and skin;
• slight chills;
• increase in body temperature.

special instructions

In order not to harm the body, when using the medication, you should follow simple rules:

1. Before starting treatment, tell your doctor about all the medicines you are taking.
2. Do not use the product if there are visual signs of unsuitability of the vial or its contents (discoloration of the powder, packaging defect).
3. Having missed the introduction of the next dose of the solution, carry out its subsequent use as usual. Doubling the dose is prohibited.
4. In case of pain at the injection site, dissolve the drug in 1 ml of a 0.25% procaine solution. You should first make sure that there is no hypersensitivity to the painkiller.
5. Do not dissolve the lyophilisate in protein-containing solutions for intravenous administration.
6. Stop using the medicine if allergic reactions occur. Cancellation of the drug is carried out without a gradual decrease in dosage.

drug interaction

Polyoxidonium for injection is usually prescribed as part of complex therapy. Depending on the etiology of the disease, the doctor may additionally prescribe anti-inflammatory, antihistamine and nonsteroidal drugs to the patient.

As well as glucocorticosteroids, vitamins, dietary supplements and antispasmodics, so this immunomodulatory drug can be combined with other medicines without causing side effects.

Terms and conditions of storage

The lyophilisate for the preparation of the solution should be stored in a dry, dark place at a temperature of 4 to 8 degrees for no more than two years from the date of issue. After the expiration date, the use of the drug is strictly prohibited.

Terms of dispensing from pharmacies

The drug is released only on prescription.

Analogues and price

The cost of the drug Polyoxidonium in the form of a lyophilizate is 700 rubles for 5 ampoules at a concentration of 3 mg. The price of 5 ampoules at a concentration of 6 mg is 1110 rubles.

Effective analogues of the drug are:

• Erbisol.
• Ribomunil.
• Cycloferon .
• Galavit.
• Immunal.

Reviews

Sergey Martynov, immunologist, candidate of medical sciences. Polyoxidonium is an effective immunomodulatory drug that can reduce the duration of illness, eliminate intoxication syndrome and reduce the incidence of disease.

Over my many years of practice, I have prescribed Polyoxidonium to both seriously ill patients and young children for the prevention of allergic conditions, influenza, acute respiratory infections, and I can note that the drug has perfectly coped with its task.

Vladimir, 44 years old, Yaroslavl. Polyoxidonium injections were prescribed to me by my attending physician. At that time, I was often sick, I could catch a cold even from a slight draft, although this had never happened before.

All of a sudden, the allergy also appeared. After the course of intramuscular injections, I have not been sick for the second year already, there is no allergic reaction to anything either. If necessary, I will definitely repeat the course.

Inna, 29 years old, Krasnodar. Used Polyoxidonium to get rid of warts on her body, since other immunostimulating and antiviral drugs did not help.

All neoplasms did not disappear, but the skin condition improved markedly. I am satisfied with the product, but expected more from it. Perhaps in time I will try another course of treatment.

Polyoxidonium treatment allows you to quickly get rid  of the unpleasant manifestations of pathological processes and eliminate the root cause of their occurrence with minimal discomfort.

With the correct use of the drug and compliance with all the doctor’s recommendations, the result of drug therapy will not be long in coming. The main thing is to start treatment in a timely manner and not to ignore the symptoms that suddenly appear.